CONSIDERATIONS TO KNOW ABOUT NR1-SITE

Employing this approach, Kalbaugh et al. assigned affinity and efficacy roles to positions during the LBDs from the NR1 and NR2A NMDAR subunits. In situ mutation of residues in direct contact with certain ligand influenced both equally efficacy and affinity, whilst positions that stabilize the shut cleft conformation without having a direct ligand